CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability
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ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC-derived excitatory neurons
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
Sonlicromanol improves neuronal netwrok dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in IPSC-derived neurons
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
m.3243A>G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity
Basal ryanodine receptor activity suppresses autophagic flux Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.(2017) Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van […]
Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse
Increased GABAB receptor signaling in a rat model for schizophrenia Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RW, van Hulten JA, van Bakel NH, Roosen J, van der Linden RJ, Schubert D, Verheij MM, Kasri NN, Martens GJ. (2016) ARHGAP12 functions as a developmental brake on excitatory synapse […]