Nadif Kasri Lab team
Based in Nijmegen, the Netherlands and led by Nael Nadif Kasri, our team is researching synaptic dysfunction in neurodevelopmental disorders.
Technicians
Molecular biology
Stem cell biology, molecular biology
Cell culture, MEA’s, hiPSCs
PhD candidates
Developing AON therapies for rare genetic disorders. Part of ZonMW TAILORED project.
In collaboration with Prof. Lisenka Vissers
Phylogenetic and ontogenetic aspects of dendrite signaling.
In collaboration with Prof. Richard van Wezel.
Studying the role of KANSL1 in brain development.
Modeling Dravet syndrome in human stem cell models.
Mitochondrial disorders. Part of EU SIMPATHIC consortium.
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Understanding the role of sex in autism. Part of NWA SCANNER project.
In collaboration with Prof. Corette Wierenga.
Studying the role of mitochondria in neurodevelopmental disorders
Developing novel multimodal MEA measurements. Part of Neur02-chip consortium.
In collaboration with Werner Koopman.
Understanding the role of microglia in neurodevelopment.
In collaboration with Lot de Witte
Understanding the role of microglia in neurodevelopmental disorders.
In collaboration with Lot de Witte
Understanding the role of microglia in neurodevelopmental disorders.
In collaboration with Lot de Witte
Postdocs
Modeling neurometabolic disorders. Developing therapies for CHD2-related disorders. Part of ZonMW TAILORED project.
Role of autophagy in neurodevelopmental disorders. Developing therapies for CHD2-related disorders. Evolution.
Role of autophagy in neurodevelopmental disorders. Modelling NDDs. Part of ZonMW BRAINmodel consortia.
Modeling Koolen de Vries syndrome. Role of DNA damage mechanism during brain development. Cilia.
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Modelling Ataxia with stem cell derived models
Understanding the role of sex in autism. Light sheet microscopy. Part of NWA SCANNER project.
In collaboration with Prof. Corette Wierenga.
Studying human synapses in health and disease
Phenotyping ASD genes, bioinformatics, MEA-seq
Developing therapies for Brunner syndrome
Role of microglia in neurodevelopmental disorders. Kleefstra syndrome.
In collaboration with Lot de Witte
Nael Nadif Kasri
Professor of Medical Neurosciences for Neurodevelopmental Disorders
I am a neuroscientist with a passion for understanding how neurons communicate—and what happens when this communication is disrupted.
As a first-generation university student, I began my academic journey in Biochemistry at the University of Leuven (2000) and developed a strong interest in calcium signaling during my PhD.
My postdoctoral work at Cold Spring Harbor Laboratory sparked my fascination with neuroscience, where I taught myself electrophysiology and became deeply interested in synaptopathies—disorders caused by disrupted synaptic function.
Radboud UMC research group
Since establishing my research group at Radboud UMC in 2011, I have focused on unraveling the molecular mechanisms behind neurodevelopmental disorders (NDDs), including
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intellectual disabilities
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autism spectrum disorder
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epilepsy
Working closely with clinicians and geneticists, we aim to advance our understanding of rare genetic conditions.
